For the 225th time in his illustrious career, Rafael Nadal grabbed a two-set lead in a Grand Slam match. For only the second time, he blew that big edge and lost. A couple of uncharacteristically sloppy overheads and a framed backhand in a third-set tiebreaker began Nadal’s undoing, and his bid for a men’s-record 21st major championship eventually ended in the Australian Open quarterfinals Wednesday with 3-6, 2-6, 7-6 (4), 6-4, 7-5 loss to Stefanos Tsitsipas