Stefanos Tsitsipas advanced to his first Western & Southern Open quarter-final on Tuesday, beating 2013 runner-up John Isner 7-6(2), 7-6(4). Tsitsipas held his nerve in two tie-break sets and won 84 per cent of first-serve points (38/45) to advance after one hour and 42 minutes. The 22-year-old improves to 15-5 this year following his second victory in four ATP Head2Head contests against Isner. Tsitsipas is bidding to reach his third straight final on the ATP Tour. In his two most recent events prior to the ATP Tour suspension, the World No. 6 lifted the Open 13 Provence trophy and finished as runner-up at the Dubai Duty Free Tennis Championships for the second straight year. Following his win against 6'10" Isner, Tsitsipas will meet another big-serving American, 6'11" Reilly Opelka, in the quarter-finals.